The Kinki Region, also commonly known as Kansai, consists of seven prefectures. It used to be the political and cultural center of Japan for many centuries. The cities of Kyoto, Osaka, Nara, and Kobe are all part of the Kinki Region.
From Tokyo, the Kinki area can be easily accessed by the JR Tokaido Shinkansen in about two to three hours. Check the individual cities' access pages for more details.