The Saikyo Line (埼京線, Saikyō-sen) connects southern Saitama Prefecture with Akabane, Ikebukuro, Shinjuku, Shibuya and Osaki.

Between Ikebukuro and Osaki, the Saikyo Line runs parallel to the Yamanote Line, but stops only at Shinjuku, Shibuya and Ebisu Stations. North of Tokyo, some trains run as far as Kawagoe.

While the Saikyo Line technically ends at Osaki Station, many trains on the Saikyo Line continue to run on the Rinkai Line from Osaki to Odaiba, before terminating at Shin-Kiba. Note, that the Rinkai Line is not owned by JR, which means that the Japan Rail Pass and similar JR tickets are not valid on it.

Below are more details about the stations of the Saikyo Line in their actual order.

Further connecting to Saitama
Akabane	Akabane is a busy train station in northern Tokyo at the border to Saitama Prefecture.
Jujo
Itabashi
Ikebukuro	Ikebukuro is one of Tokyo's largest shopping and entertainment districts. Several suburban train lines commence at Ikebukuro Station.
Shinjuku	Shinjuku Station is Japan's busiest train station. It is located in the middle of the large Shinjuku business, entertainment and shopping district. Many suburban train lines commence at Shinjuku Station.
Shibuya	Shibuya is a large shopping and business district particularly popular among the younger generations. Several suburban train lines commence at Shibuya Station.
Ebisu	Closest station to Yebisu Garden Place.
Osaki
Oimachi
Shinagawa Seaside
Tennozu Isle
Tokyo Teleport	This is the closest station to Odaiba, the futuristic entertainment and shopping district in the Tokyo Bay area.
Kokusai-Tenjijo	Tokyo Big Sight, a futuristic looking exhibition hall is located close to Kokusai-Tenjijo Station.
Shinonome
Shin-Kiba

JR Yamanote Line
JR Keihin-Tohoku Line
JR Chuo Line
JR Saikyo Line
JR Shonan Shinjuku Line